{"id":1015,"date":"2020-11-25T12:40:46","date_gmt":"2020-11-25T12:40:46","guid":{"rendered":"https:\/\/wordpress-486734-1610623.cloudwaysapps.com\/?page_id=1015"},"modified":"2026-02-10T13:45:18","modified_gmt":"2026-02-10T12:45:18","slug":"home","status":"publish","type":"page","link":"https:\/\/innosciencelab.com\/hu\/","title":{"rendered":"Kezd\u0151lap"},"content":{"rendered":"<style>.kb-row-layout-id1015_535f29-33 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1015_535f29-33 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1015_535f29-33 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:var( --global-content-width, 1290px );padding-left:var(--global-content-edge-padding);padding-right:var(--global-content-edge-padding);padding-top:var(--global-kb-spacing-md, 2rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1015_535f29-33{background-color:#ffffff;}.kb-row-layout-id1015_535f29-33 > .kt-row-layout-overlay{opacity:0.00;background-color:#ffffff;}@media all and (max-width: 1024px){.kb-row-layout-id1015_535f29-33 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1015_535f29-33 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1015_535f29-33 alignnone kt-row-has-bg wp-block-kadence-rowlayout\"><div class=\"kt-row-layout-overlay kt-row-overlay-normal\"><\/div><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top kb-theme-content-width\">\n<style>.kadence-column1015_140964-17 > .kt-inside-inner-col{display:flex;}.kadence-column1015_140964-17 > .kt-inside-inner-col{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.kadence-column1015_140964-17 > .kt-inside-inner-col{row-gap:var(--global-kb-gap-none, 0rem );column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1015_140964-17 > .kt-inside-inner-col{flex-direction:column;align-items:flex-start;}.kadence-column1015_140964-17 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1015_140964-17 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1015_140964-17 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1015_140964-17 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1015_140964-17 > .kt-inside-inner-col:before{opacity:1;mix-blend-mode:normal;background-color:#ffffff;}.kadence-column1015_140964-17{text-align:left;}.kadence-column1015_140964-17{position:relative;}.kadence-column1015_140964-17, .kt-inside-inner-col > .kadence-column1015_140964-17:not(.specificity){margin-top:0px;margin-right:var(--global-kb-spacing-sm, 1.5rem);margin-left:var(--global-kb-spacing-sm, 1.5rem);}@media all and (max-width: 1024px){.kadence-column1015_140964-17 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:flex-start;}}@media all and (max-width: 767px){.kadence-column1015_140964-17 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:flex-start;}}.kadence-column1015_140964-17 {  box-shadow: 0px 10px 50px 10px rgba(0,0,250,0.3);  padding: 40px;  border-radius: 20px;  margin-top: -100px;  background: #FFFFFF;  max-width: 870px;  justify-self: center;}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1015_140964-17 kb-section-has-overlay kb-section-dir-vertical\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-advancedheading.kt-adv-heading1015_9b5c83-27, .wp-block-kadence-advancedheading.kt-adv-heading1015_9b5c83-27[data-kb-block=\"kb-adv-heading1015_9b5c83-27\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading1015_9b5c83-27 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading1015_9b5c83-27[data-kb-block=\"kb-adv-heading1015_9b5c83-27\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading1015_9b5c83-27 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading1015_9b5c83-27[data-kb-block=\"kb-adv-heading1015_9b5c83-27\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading1015_9b5c83-27 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading1015_9b5c83-27\">Abstract<\/h2>\n\n\n\n<p class=\"justify-text wp-block-paragraph\">Welcome to Innoscience Hungary Ltd, a non-profit research company dedicated to advancing brain disease research through molecular, proteomic, physiological, and electrophysiological methodologies. With decades of experience, we aim to create a high-tech, supportive research ecosystem for graduate students, PhD students and postdoctoral researchers. By combining budget-based and non-budget resources, including private donations and grants, we ensure a stable and productive environment. Our goal is to retain talented researchers in Hungary, counterbalancing the challenges posed by limited funding and technological resources, and ultimately to support the translation of exploratory research results into diagnostic and therapeutic innovation.<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns1015_df8ce8-b2{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:flex-start;align-items:center;}.kt-btns1015_df8ce8-b2 .kt-button{font-weight:normal;font-style:normal;}.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns1015_df8ce8-b2 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns1015_df8ce8-b2\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn1015_830a6b-dd.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn1015_830a6b-dd.kb-button{font-family:Rubik;font-weight:600;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;padding:var(--kb-btn-padding);margin:var(--kb-btn-margin);padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-md, 2rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-md, 2rem);box-shadow:none;}.wp-block-kadence-advancedbtn .kb-btn1015_830a6b-dd.kb-button:hover, .wp-block-kadence-advancedbtn .kb-btn1015_830a6b-dd.kb-button:focus{box-shadow:var(--kb-btn-shadow-hover, none);}<\/style><a class=\"kb-button kt-button button kb-btn1015_830a6b-dd kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-fill kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/innosciencelab.com\/publications\/\"><span class=\"kt-btn-inner-text\">OUR PUBLICATIONS<\/span><\/a><\/div>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1015_4ec30c-bd > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1015_4ec30c-bd > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1015_4ec30c-bd > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1015_4ec30c-bd > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1015_4ec30c-bd > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1015_4ec30c-bd > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1015_4ec30c-bd alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1015_c22974-fd > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1015_c22974-fd > .kt-inside-inner-col{flex-direction:column;}.kadence-column1015_c22974-fd > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1015_c22974-fd > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1015_c22974-fd{position:relative;}@media all and (max-width: 1024px){.kadence-column1015_c22974-fd > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1015_c22974-fd > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1015_c22974-fd\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-advancedheading.kt-adv-heading1015_5616c1-d8, .wp-block-kadence-advancedheading.kt-adv-heading1015_5616c1-d8[data-kb-block=\"kb-adv-heading1015_5616c1-d8\"]{text-align:center;font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading1015_5616c1-d8 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading1015_5616c1-d8[data-kb-block=\"kb-adv-heading1015_5616c1-d8\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading1015_5616c1-d8 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading1015_5616c1-d8[data-kb-block=\"kb-adv-heading1015_5616c1-d8\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading1015_5616c1-d8 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading1015_5616c1-d8\">Our collaborations and partnerships over the years:<\/h2>\n\n\n\n<div class=\"logo-carousel-container\">\n  <div class=\"logo-carousel\">\n    <img decoding=\"async\" src=\"http:\/\/innosciencelab.com\/wp-content\/uploads\/2024\/08\/Logok.png\" alt=\"Collaborator Logos\" class=\"logo-image\">\n    <img decoding=\"async\" src=\"http:\/\/innosciencelab.com\/wp-content\/uploads\/2024\/08\/Logok.png\" alt=\"Collaborator Logos\" class=\"logo-image\">\n  <\/div>\n  <div class=\"fade-left\"><\/div>\n  <div class=\"fade-right\"><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kt-tabs-id1015_84a72d-d5 > .kt-tabs-content-wrap > .wp-block-kadence-tab{border-top:0px solid var(--global-palette7, #eeeeee);border-right:0px solid var(--global-palette7, #eeeeee);border-bottom:0px solid var(--global-palette7, #eeeeee);border-left:0px solid var(--global-palette7, #eeeeee);border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-right:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);padding-left:var(--global-kb-spacing-sm, 1.5rem);min-height:448px;background:var(--global-palette9, #ffffff);}.wp-block-kadence-tabs .kt-tabs-id1015_84a72d-d5 > .kt-tabs-title-list li{margin-top:0px;margin-right:-4px;margin-bottom:10px;margin-left:0px;}.wp-block-kadence-tabs .kt-tabs-id1015_84a72d-d5 > .kt-tabs-title-list li .kt-tab-title, .wp-block-kadence-tabs .kt-tabs-id1015_84a72d-d5 > .kt-tabs-content-wrap > .kt-tabs-accordion-title 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solid var(--global-palette7, #eeeeee);border-bottom:0px solid var(--global-palette7, #eeeeee);border-left:0px solid var(--global-palette7, #eeeeee);}}<\/style>\n<div class=\"wp-block-kadence-tabs alignnone\"><div class=\"kt-tabs-wrap kt-tabs-id1015_84a72d-d5 kt-tabs-has-4-tabs kt-active-tab-1 kt-tabs-layout-vtabs kt-tabs-tablet-layout-inherit kt-tabs-mobile-layout-accordion kt-tab-alignment-left kt-create-accordion\"><ul class=\"kt-tabs-title-list\"><li id=\"tab-molecular\" class=\"kt-title-item kt-title-item-1 kt-tabs-svg-show-always kt-tabs-icon-side-left kt-tab-title-active kb-tabs-have-subtitle\"><a href=\"#tab-molecular\" data-tab=\"1\" class=\"kt-tab-title kt-tab-title-1 \"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_chevronRight\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><polyline points=\"9 18 15 12 9 6\"\/><\/svg><\/span><div class=\"kb-tab-titles-wrap\"><span class=\"kt-title-text\">Molecular<\/span><span class=\"kt-title-sub-text\">Biochemical pathways contributing to brain diseases.<\/span><\/div><\/a><\/li><li id=\"tab-cellular\" class=\"kt-title-item kt-title-item-2 kt-tabs-svg-show-always kt-tabs-icon-side-left kt-tab-title-inactive kb-tabs-have-subtitle\"><a href=\"#tab-cellular\" data-tab=\"2\" class=\"kt-tab-title kt-tab-title-2 \"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_chevronRight\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><polyline points=\"9 18 15 12 9 6\"\/><\/svg><\/span><div class=\"kb-tab-titles-wrap\"><span class=\"kt-title-text\">Cellular<\/span><span class=\"kt-title-sub-text\">Cellular dynamics and interactions in the nervous system.<\/span><\/div><\/a><\/li><li id=\"tab-developmental\" class=\"kt-title-item kt-title-item-3 kt-tabs-svg-show-always kt-tabs-icon-side-left kt-tab-title-inactive kb-tabs-have-subtitle\"><a href=\"#tab-developmental\" data-tab=\"3\" class=\"kt-tab-title kt-tab-title-3 \"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_chevronRight\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><polyline points=\"9 18 15 12 9 6\"\/><\/svg><\/span><div class=\"kb-tab-titles-wrap\"><span class=\"kt-title-text\">Developmental<\/span><span class=\"kt-title-sub-text\">Immune-nervous system interactions during development as a basis for neuropsychiatric diseases.<\/span><\/div><\/a><\/li><li id=\"tab-behavioral\" class=\"kt-title-item kt-title-item-4 kt-tabs-svg-show-always kt-tabs-icon-side-left kt-tab-title-inactive kb-tabs-have-subtitle\"><a href=\"#tab-behavioral\" data-tab=\"4\" class=\"kt-tab-title kt-tab-title-4 \"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_chevronRight\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><polyline points=\"9 18 15 12 9 6\"\/><\/svg><\/span><div class=\"kb-tab-titles-wrap\"><span class=\"kt-title-text\">Behavioral<\/span><span class=\"kt-title-sub-text\">Behavioral neuroscience of particular disease states.<\/span><\/div><\/a><\/li><\/ul><div class=\"kt-tabs-content-wrap\">\n<div class=\"wp-block-kadence-tab kt-tab-inner-content kt-inner-tab-1 kt-inner-tab1015_326e59-67\"><div class=\"kt-tab-inner-content-inner\"><div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"640\" src=\"https:\/\/innosciencelab.com\/wp-content\/uploads\/2024\/09\/chemist_12894255-6.gif\" alt=\"\" class=\"wp-image-2706\" style=\"width:236px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"justify-text wp-block-paragraph\">We quantify brain pathology as measurable molecular signatures &#8211; synaptic proteome remodeling, mitochondrial\/MAM proteostasis shifts, and extracellular peptidome dynamics &#8211; captured across regions and disease-relevant perturbations. Our molecular readouts are explicitly designed to map onto physiology and behavior.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"inno-modal-scope\">\n\n  <!-- Featured evidence (TRIGGERS \/ CHIPS) -->\n  <div class=\"inno-chip-wrap\">\n    <span class=\"inno-chip-label\">Featured evidence<\/span>\n\n    <div class=\"inno-chip-row\">\n      <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-mol-1\">\n        Region-specific synaptic remodeling\n      <\/button>\n\n      <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-mol-2\">\n        CSF reflects mitochondrial\/MAM proteostasis\n      <\/button>\n\n      <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-mol-3\">\n        Extracellular peptidome during seizures\n      <\/button>\n    <\/div>\n  <\/div>\n\n  <!-- MODAL 1 -->\n  <div class=\"inno-modal\" id=\"inno-mol-1\" aria-hidden=\"true\">\n    <div class=\"inno-overlay\" data-inno-close><\/div>\n\n    <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-mol-1-title\">\n      <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n      <h3 id=\"inno-mol-1-title\" class=\"inno-title\">Region-specific synaptic remodeling<\/h3>\n\n      <p class=\"inno-body\">\n        <strong>Model:<\/strong> Stepwise bilateral common carotid occlusion (Wistar rat).<br>\n        <strong>Readout:<\/strong> Synaptic proteome by 2D-DIGE; IDs by LC\u2013MS\/MS.<br>\n        <strong>Key result:<\/strong> 94 vs 33 vs 17 altered synaptic proteins across occipital cortex, frontal cortex, hippocampus.<br>\n        <strong>Why it matters:<\/strong> Quantifies region-specific vulnerability and mechanistic pathways.\n      <\/p>\n\n      <p class=\"inno-links\">\n        <a href=\"https:\/\/www.nature.com\/articles\/s41598-020-72868-w\" target=\"_blank\" rel=\"noopener\">\n          Read the paper\n        <\/a>\n      <\/p>\n    <\/div>\n  <\/div>\n\n  <!-- MODAL 2 -->\n  <div class=\"inno-modal\" id=\"inno-mol-2\" aria-hidden=\"true\">\n    <div class=\"inno-overlay\" data-inno-close><\/div>\n\n    <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-mol-2-title\">\n      <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n      <h3 id=\"inno-mol-2-title\" class=\"inno-title\">CSF reflects mitochondrial\/MAM proteostasis<\/h3>\n\n      <p class=\"inno-body\">\n        <strong>Model:<\/strong> Chronic cerebral hypoperfusion (Wistar rat).<br>\n        <strong>Readout:<\/strong> Proteomics of mitochondria, mitochondria-associated membranes (MAM), and cerebrospinal fluid (CSF); targeted validation by Western blot.<br>\n        <strong>Key result:<\/strong> Changes across compartments (mitochondria: 19; MAM: 35; CSF: 12), consistent with altered protein turnover\/import processes; WB validation included P4HB and HIBADH.<br>\n        <strong>Why it matters:<\/strong> Supports CSF-accessible molecular signatures that reflect intracellular organelle proteostasis.\n      <\/p>\n\n      <p class=\"inno-links\">\n        <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03215-z\" target=\"_blank\" rel=\"noopener\">\n          Read the paper\n        <\/a>\n      <\/p>\n    <\/div>\n  <\/div>\n\n  <!-- MODAL 3 -->\n  <div class=\"inno-modal\" id=\"inno-mol-3\" aria-hidden=\"true\">\n    <div class=\"inno-overlay\" data-inno-close><\/div>\n\n    <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-mol-3-title\">\n      <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n      <h3 id=\"inno-mol-3-title\" class=\"inno-title\">Extracellular peptidome during seizures<\/h3>\n\n      <p class=\"inno-body\">\n        <strong>Model:<\/strong> Hippocampal 4-aminopyridine (4-AP) seizure paradigm (Wistar rat).<br>\n        <strong>Readout:<\/strong> Hippocampal microdialysis coupled to LC\u2013MS\/MS peptidomics.<br>\n        <strong>Key result:<\/strong> 2,540 extracellular peptides detected; 322 peptides were significantly altered during 4-AP seizures.<br>\n        <strong>Why it matters:<\/strong> Provides a quantitative extracellular-space signature of acute circuit disruption, enabling hypothesis-driven follow-up on peptide sources and pathways.\n      <\/p>\n\n      <p class=\"inno-links\">\n        <a href=\"https:\/\/www.mdpi.com\/2076-3425\/15\/8\/881\" target=\"_blank\" rel=\"noopener\">\n          Read the paper\n        <\/a>\n      <\/p>\n    <\/div>\n  <\/div>\n\n<\/div>\n\n<style>\n\/* Scope everything so Kadence\/global styles don\u2019t break it *\/\n.inno-modal-scope { font: inherit; }\n\n\/* Grouping \/ wrapper *\/\n.inno-chip-wrap{ margin-top:.75rem !important; }\n.inno-chip-label{\n  display:block !important;\n  font-size:.9rem !important;\n  font-weight:600 !important;\n  opacity:.8 !important;\n  margin:0 0 .5rem 0 !important;\n}\n.inno-chip-row{\n  display:flex !important;\n  flex-wrap:wrap !important;\n  gap:.6rem .6rem !important;\n  align-items:flex-start !important;\n}\n\n\/* Chip *\/\n.inno-chip{\n  display:inline-flex !important;\n  align-items:center !important;\n  justify-content:center !important;\n  padding:.55rem .95rem !important;\n  border-radius:999px !important;\n\n  border: 1px solid #1e5eff !important;\n  background: transparent !important;\n  color: #1e5eff !important;\n\n  font: inherit !important;\n  font-weight: 600 !important;\n  line-height: 1.1 !important;\n  cursor:pointer !important;\n\n  appearance:none !important;\n  -webkit-appearance:none !important;\n\n  max-width:100% !important;\n  white-space: normal !important;\n  text-align:left !important;\n}\n.inno-chip:hover,\n.inno-chip:focus{\n  background: rgba(30,94,255,.10) !important; \/* blue-ish hover *\/\n}\n.inno-chip:focus{\n  outline:2px solid currentColor !important;\n  outline-offset:2px !important;\n}\n\n\/* Modal wrapper *\/\n.inno-modal{\n  position:fixed !important;\n  inset:0 !important;\n  z-index:999999 !important;\n\n  display:flex !important;\n  align-items:center !important;\n  justify-content:center !important;\n\n  opacity:0 !important;\n  pointer-events:none !important;\n  transition: opacity .15s ease !important;\n}\n.inno-modal[aria-hidden=\"false\"]{\n  opacity:1 !important;\n  pointer-events:auto !important;\n}\n\n\/* Overlay *\/\n.inno-overlay{\n  position:absolute !important;\n  inset:0 !important;\n  background:rgba(0,0,0,.55) !important;\n}\n\n\/* Dialog *\/\n.inno-dialog{\n  position:relative !important;\n  width:min(720px, calc(100vw - 2rem)) !important;\n  max-height:calc(100vh - 6rem) !important;\n  overflow:auto !important;\n\n  background:#fff !important;\n  color:#111 !important;\n  border-radius:16px !important;\n  padding:1.25rem 1.25rem 1rem !important;\n\n  box-shadow:0 10px 30px rgba(0,0,0,.25) !important;\n  box-sizing:border-box !important;\n}\n\n\/* Close button *\/\n.inno-close{\n  position:absolute !important;\n  top:.6rem !important;\n  right:.8rem !important;\n\n  width:2.25rem !important;\n  height:2.25rem !important;\n\n  display:flex !important;\n  align-items:center !important;\n  justify-content:center !important;\n\n  padding:0 !important;\n  margin:0 !important;\n  line-height:1 !important;\n\n  border-radius:10px !important;\n  border:1px solid rgba(0,0,0,.2) !important;\n  background:rgba(0,0,0,.04) !important;\n  color:#111 !important;\n\n  font-size:1.4rem !important;\n  cursor:pointer !important;\n}\n\n\/* Typography *\/\n.inno-title{ margin:0 0 .75rem 0 !important; }\n.inno-body{ margin:0 0 1rem 0 !important; }\n.inno-links{ margin:0 !important; }\n\n@media (max-width: 640px){\n  .inno-dialog{ max-height:calc(100vh - 3rem) !important; }\n}\n<\/style>\n\n<script>\n(function(){\n  function openModal(id){\n    const modal = document.getElementById(id);\n    if(!modal) return;\n    modal.setAttribute('aria-hidden','false');\n    document.documentElement.style.overflow = 'hidden';\n  }\n  function closeModal(modal){\n    modal.setAttribute('aria-hidden','true');\n    document.documentElement.style.overflow = '';\n  }\n\n  document.addEventListener('click', function(e){\n    const openBtn = e.target.closest('[data-inno-open]');\n    if(openBtn){\n      openModal(openBtn.getAttribute('data-inno-open'));\n      return;\n    }\n    const closeBtn = e.target.closest('[data-inno-close]');\n    if(closeBtn){\n      const modal = e.target.closest('.inno-modal');\n      if(modal) closeModal(modal);\n    }\n  });\n\n  document.addEventListener('keydown', function(e){\n    if(e.key !== 'Escape') return;\n    document.querySelectorAll('.inno-modal[aria-hidden=\"false\"]').forEach(closeModal);\n  });\n})();\n<\/script>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-tab kt-tab-inner-content kt-inner-tab-2 kt-inner-tab1015_345c9c-d8\"><div class=\"kt-tab-inner-content-inner\"><div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"640\" src=\"https:\/\/innosciencelab.com\/wp-content\/uploads\/2024\/09\/nerve-cell_17275911-1.gif\" alt=\"\" class=\"wp-image-2680\" style=\"width:230px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"justify-text wp-block-paragraph\">We connect single-neuron physiology to single-cell molecular programs. Our work pairs electrophysiology with ultra-deep single-cell transcriptomics to define cell-type-resolved targets and immune signatures, and includes mechanistic studies of cellular homeostasis pathways in neurons.<\/p>\n\n\n\n<!-- CELLULAR: Featured evidence (TRIGGERS \/ CHIPS) -->\n<div class=\"inno-chip-wrap\">\n  <span class=\"inno-chip-label\">Featured evidence<\/span>\n\n  <div class=\"inno-chip-row\">\n    <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-cell-1\">\n      Electrophysiology + scRNA-seq\n    <\/button>\n\n    <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-cell-2\">\n      Neuronal immune\/AMP transcript programs\n    <\/button>\n\n    <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-cell-3\">\n      Septin-3 and neuronal autophagy\n    <\/button>\n  <\/div>\n<\/div>\n\n<!-- CELLULAR MODAL 1 -->\n<div class=\"inno-modal\" id=\"inno-cell-1\" aria-hidden=\"true\">\n  <div class=\"inno-overlay\" data-inno-close><\/div>\n\n  <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-cell-1-title\">\n    <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n    <h3 id=\"inno-cell-1-title\" class=\"inno-title\">Electrophysiology + ultra-deep single-cell RNA-seq (PFC)<\/h3>\n\n    <p class=\"inno-body\">\n      <strong>System:<\/strong> Mouse prefrontal cortex (acute slices).<br>\n      <strong>Approach:<\/strong> Electrophysiological identification of single neurons followed by ultra-deep single-cell mRNA sequencing.<br>\n      <strong>Key result:<\/strong> High transcriptomic coverage (19,685 transcripts total) enabling cell-type-resolved assignment of candidate cell-surface and \u201cdruggable\u201d targets to pyramidal vs fast-spiking interneuron classes.<br>\n      <strong>Why it matters:<\/strong> Ties functional phenotype to molecular accessibility at single-cell resolution.\n    <\/p>\n\n    <p class=\"inno-links\">\n      <a href=\"https:\/\/academic.oup.com\/cercor\/article\/31\/2\/731\/5876102\" target=\"_blank\" rel=\"noopener\">\n        Read the paper\n      <\/a>\n    <\/p>\n  <\/div>\n<\/div>\n\n<!-- CELLULAR MODAL 2 -->\n<div class=\"inno-modal\" id=\"inno-cell-2\" aria-hidden=\"true\">\n  <div class=\"inno-overlay\" data-inno-close><\/div>\n\n  <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-cell-2-title\">\n    <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n    <h3 id=\"inno-cell-2-title\" class=\"inno-title\">Neuronal immune\/AMP transcript programs<\/h3>\n\n    <p class=\"inno-body\">\n      <strong>System:<\/strong> Electrophysiologically identified prefrontal pyramidal cells and fast-spiking interneurons (single-cell dataset).<br>\n      <strong>Approach:<\/strong> Targeted bioinformatic re-analysis focusing on antimicrobial peptides (AMPs) and immune-process genes.<br>\n      <strong>Key result:<\/strong> Detection of a large fraction of AMP-related transcripts (~53%) and immune cell protein-related transcripts (~94%) across 84 neurons, with cell-type-enriched patterns.<br>\n      <strong>Why it matters:<\/strong> Supports mechanistic hypotheses for neuron-to-immune communication pathways in cortex.\n    <\/p>\n\n    <p class=\"inno-links\">\n      <a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2021.749433\/full\" target=\"_blank\" rel=\"noopener\">\n        Read the paper\n      <\/a>\n    <\/p>\n  <\/div>\n<\/div>\n\n<!-- CELLULAR MODAL 3 -->\n<div class=\"inno-modal\" id=\"inno-cell-3\" aria-hidden=\"true\">\n  <div class=\"inno-overlay\" data-inno-close><\/div>\n\n  <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-cell-3-title\">\n    <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n    <h3 id=\"inno-cell-3-title\" class=\"inno-title\">Septin-3 and neuronal autophagy<\/h3>\n\n    <p class=\"inno-body\">\n      <strong>System:<\/strong> Primary neuronal cultures and cortical slices (mouse).<br>\n      <strong>Approach:<\/strong> Biochemical binding assays + neuronal imaging under autophagy induction\/inhibition; ultrastructural localization.<br>\n      <strong>Key result:<\/strong> Septin-3 binds LC3B (and GABARAPL2), and septin-3\/LC3B colocalization increases upon autophagy induction in neurons.<br>\n      <strong>Why it matters:<\/strong> Provides a concrete molecular handle to study autophagy-linked synaptic\/cellular homeostasis mechanisms in neurons.\n    <\/p>\n\n    <p class=\"inno-links\">\n      <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04488-8\" target=\"_blank\" rel=\"noopener\">\n        Read the paper\n      <\/a>\n    <\/p>\n  <\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-tab kt-tab-inner-content kt-inner-tab-3 kt-inner-tab1015_1705eb-aa\"><div class=\"kt-tab-inner-content-inner\"><div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"640\" src=\"https:\/\/innosciencelab.com\/wp-content\/uploads\/2024\/10\/nervous-system_17275967.gif\" alt=\"\" class=\"wp-image-2773\" style=\"width:231px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<p class=\"justify-text wp-block-paragraph\">At the developmental level, we study how neural circuits and immune responses evolve over time and under different conditions. The Luminex MAGPIX cytokine assay allows for the multiplexed measurement of cytokines and other immune markers, providing insight into neuro-immune interactions that influence brain development and disease. Together with techniques like microdialysis we can analyze the biochemical environment of the brain, monitoring changes in neurotransmitter and cytokine levels to understand how these factors shape neural development.<\/p>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-tab kt-tab-inner-content kt-inner-tab-4 kt-inner-tab1015_512e1a-b2\"><div class=\"kt-tab-inner-content-inner\"><div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"640\" src=\"https:\/\/innosciencelab.com\/wp-content\/uploads\/2024\/10\/rat_11684077.gif\" alt=\"\" class=\"wp-image-2775\" style=\"width:229px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<p class=\"justify-text wp-block-paragraph\">At the behavioral level, we quantify how molecular and circuit perturbations translate into learning, memory and exploratory phenotypes in rodents. We combine standardized behavioral paradigms with high-resolution, video-based tracking (e.g., DeepLabCut, SimBa, MoSeq) and automated scoring to obtain reproducible, fine-grained measures of behavior. By integrating these outputs with physiological and molecular readouts, we test mechanistic links between synaptic function and behavior in disease-relevant models.<\/p>\n<\/div>\n\n\n\n<!-- BEHAVIORAL: Featured evidence (TRIGGER \/ CHIP) -->\n<div class=\"inno-chip-wrap\">\n  <span class=\"inno-chip-label\">Featured evidence<\/span>\n\n  <div class=\"inno-chip-row\">\n    <button class=\"inno-chip\" type=\"button\" data-inno-open=\"inno-beh-peptide\">\n      Short interfering peptide probe (Arc\u2013TARP\u03b32)\n    <\/button>\n  <\/div>\n<\/div>\n\n<!-- BEHAVIORAL MODAL -->\n<div class=\"inno-modal\" id=\"inno-beh-peptide\" aria-hidden=\"true\">\n  <div class=\"inno-overlay\" data-inno-close><\/div>\n\n  <div class=\"inno-dialog\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"inno-beh-peptide-title\">\n    <button class=\"inno-close\" type=\"button\" data-inno-close aria-label=\"Close\">\u00d7<\/button>\n\n    <h3 id=\"inno-beh-peptide-title\" class=\"inno-title\">Exploratory short-peptide interference in vivo<\/h3>\n\n    <p class=\"inno-body\">\n      <strong>System:<\/strong> In vivo electrophysiology; spatial memory assays (Wistar rat).<br>\n      <strong>Approach:<\/strong> Short interfering peptide <em>RIPSYR<\/em> designed to perturb the Arc\u2013TARP\u03b32 interaction.<br>\n      <strong>Key result:<\/strong> Peptide interference altered early-phase LTP and was associated with reduced spatial memory retrieval.<br>\n      <strong>Why it matters:<\/strong> Provides a proof-of-principle workflow for using short peptides as exploratory perturbation tools linking molecular interactions to circuit and behavioral readouts.\n    <\/p>\n\n    <p class=\"inno-links\">\n      <a href=\"https:\/\/www.mdpi.com\/2076-3425\/15\/8\/881\" target=\"_blank\" rel=\"noopener\">\n        Read the paper\n      <\/a>\n    <\/p>\n  <\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<style>.kb-row-layout-id1015_c00202-07 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1015_c00202-07 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1015_c00202-07 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1015_c00202-07 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1015_c00202-07 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1015_c00202-07 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1015_c00202-07 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1015_8859d8-5a > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1015_8859d8-5a > .kt-inside-inner-col{flex-direction:column;}.kadence-column1015_8859d8-5a > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1015_8859d8-5a > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1015_8859d8-5a{position:relative;}@media all and (max-width: 1024px){.kadence-column1015_8859d8-5a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1015_8859d8-5a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1015_8859d8-5a\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1015_695fb2-91 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1015_695fb2-91 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1015_695fb2-91 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1015_695fb2-91 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1015_695fb2-91 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1015_695fb2-91 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1015_695fb2-91 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1015_91f188-17 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1015_91f188-17 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1015_91f188-17 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1015_91f188-17 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1015_91f188-17{position:relative;}@media all and (max-width: 1024px){.kadence-column1015_91f188-17 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1015_91f188-17 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1015_91f188-17\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Abstract Welcome to Innoscience Hungary Ltd, a non-profit research company dedicated to advancing brain disease research through molecular, proteomic, physiological, and electrophysiological methodologies. With decades of experience, we aim to create a high-tech, supportive research ecosystem for graduate students, PhD students and postdoctoral researchers. By combining budget-based and non-budget resources, including private donations and grants,&#8230;<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":true,"_kad_post_transparent":"enable","_kad_post_title":"hide","_kad_post_layout":"fullwidth","_kad_post_sidebar_id":"","_kad_post_content_style":"unboxed","_kad_post_vertical_padding":"hide","_kad_post_feature":"hide","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"class_list":["post-1015","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/pages\/1015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/comments?post=1015"}],"version-history":[{"count":183,"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/pages\/1015\/revisions"}],"predecessor-version":[{"id":2894,"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/pages\/1015\/revisions\/2894"}],"wp:attachment":[{"href":"https:\/\/innosciencelab.com\/hu\/wp-json\/wp\/v2\/media?parent=1015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}